In this I explained how to change the default SharePoint drafts folder from
My documents/SharePoint Drafts to another location.
If you have to change this settings for more than 300 users this is not a job you want to do by hand, so here is a possible solution that might work:
Create 2 files:
1) sharepointdraftslocation.reg, this file contains the register keys that need to be added or altered.
Windows Registry Editor Version 5.00
"Location"="C:\\Users\\tom.vangaever.NEOMATICS\\Documents\\Other SharePoint Drafts\\"
2) sharepointdraftslocation.bat, this file will use the builtin REGEDIT.EXE application to add the correct register values in to the register.
REGEDIT.EXE -S sharepointdraftslocation.reg
By using an active directory group policy you can make sure that this sharepointdraftslocation.bat script is started each time the user logins in on a computer.